C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra m\u1ed9t c\u01a1 ch\u1ebf m\u1edbi gi\u00fap th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh ch\u1eefa l\u00e0nh v\u1ebft th\u01b0\u01a1ng tr\u00ean da.<\/p>\n
Con \u0111\u01b0\u1eddng ph\u00e2n t\u1eed \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1edfi m\u1ed9t gen b\u1ea3o t\u1ed3n ti\u1ebfn h\u00f3a \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 Grainyhead like 3 (GRHL3), l\u00e0 m\u1ed9t gen c\u1ea7n thi\u1ebft cho s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa. N\u1ebfu kh\u00f4ng c\u00f3 gen n\u00e0y, m\u1ed9t s\u1ed1 b\u1ea5t th\u01b0\u1eddng c\u00f3 th\u1ec3 x\u1ea3y ra, bao g\u1ed3m t\u1eadt n\u1ee9t \u0111\u1ed1t s\u1ed1ng, h\u00e0ng r\u00e0o bi\u1ec3u b\u00ec khi\u1ebfm khuy\u1ebft, m\u00ed m\u1eaft b\u1ecb l\u1ed7i kh\u00e9p k\u00edn v\u00e0 h\u1ed9i ch\u1ee9ng m\u00f4 m\u1ec1m, t\u00ecnh tr\u1ea1ng tr\u1ebb em \u0111\u01b0\u1ee3c sinh ra v\u1edbi c\u00e1c ng\u00f3n tay h\u1ee3p nh\u1ea5t ho\u1eb7c c\u00f3 m\u00e0ng.<\/p>\n
Nghi\u00ean c\u1ee9u cho th\u1ea5y c\u00e1ch th\u1ee9c ho\u1ea1t \u0111\u1ed9ng trong qu\u00e1 tr\u00ecnh ch\u1eefa l\u00e0nh v\u1ebft th\u01b0\u01a1ng, GRHL3 ho\u1ea1t \u0111\u1ed9ng \u0111\u1ec3 k\u00edch ho\u1ea1t m\u1ed9t gen m\u00e3 h\u00f3a protein g\u1ecdi l\u00e0 Fascin Actin-Bundling Protein 1 (FSCN1), \u0111\u1ec3 n\u1edbi l\u1ecfng s\u1ef1 k\u1ebft d\u00ednh gi\u1eefa c\u00e1c t\u1ebf b\u00e0o da b\u1ecb th\u01b0\u01a1ng \u0111\u1ec3 ch\u00fang c\u00f3 th\u1ec3 di chuy\u1ec3n hi\u1ec7u qu\u1ea3 \u0111\u1ec3 \u0111\u00f3ng v\u1ebft th\u01b0\u01a1ng.<\/p>\n
C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u0169ng ph\u00e1t hi\u1ec7n ra r\u1eb1ng nh\u1eefng thay \u0111\u1ed5i trong qu\u00e1 tr\u00ecnh n\u00e0y c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn c\u00e1c v\u1ebft th\u01b0\u01a1ng m\u00e3n t\u00ednh, kh\u00f4ng l\u00e0nh, ch\u1eb3ng h\u1ea1n nh\u01b0 v\u1ebft lo\u00e9t do ti\u1ec3u \u0111\u01b0\u1eddng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u00e0ng tri\u1ec7u b\u1ec7nh nh\u00e2n m\u1ed7i n\u0103m.<\/p>\n
\u201cC\u00f3 chuy\u1ec7n g\u00ec th\u00fa v\u1ecb v\u1ec1 nh\u1eefng ph\u00e1t hi\u1ec7n c\u1ee7a ch\u00fang t\u00f4i l\u00e0 ch\u00fang t\u00f4i \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c m\u1ed9t \u0111\u01b0\u1eddng ph\u00e2n t\u1eed m\u00e0 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t trong v\u1ebft th\u01b0\u01a1ng c\u1ea5p t\u00ednh b\u00ecnh th\u01b0\u1eddng \u1edf ng\u01b0\u1eddi, v\u00e0 thay \u0111\u1ed5i trong v\u1ebft th\u01b0\u01a1ng ti\u1ec3u \u0111\u01b0\u1eddng \u1edf chu\u1ed9t\u201d, Ghaidaa Kashgari, m\u1ed9t nh\u00e0 nghi\u00ean c\u1ee9u sau ti\u1ebfn s\u0129 t\u1ea1i \u0110\u1ea1i h\u1ecdc California, Irvine, Tr\u01b0\u1eddng n\u00f3i Khoa Y d\u01b0\u1ee3c, cho bi\u1ebft. \u201cPh\u00e1t hi\u1ec7n n\u00e0y ch\u1ec9 ra r\u00f5 r\u00e0ng s\u1ef1 li\u00ean quan v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng v\u00e0 c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n hi\u1ec3u bi\u1ebft c\u1ee7a ch\u00fang ta v\u1ec1 sinh h\u1ecdc ch\u1eefa l\u00e0nh v\u1ebft th\u01b0\u01a1ng v\u00e0 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn c\u00e1c li\u1ec7u ph\u00e1p m\u1edbi\u201d.<\/p>\n
Qu\u00e1 tr\u00ecnh ch\u1eefa l\u00e0nh v\u1ebft th\u01b0\u01a1ng da c\u1ea5p t\u00ednh ti\u1ebfn tri\u1ec3n qua b\u1ed1n giai \u0111o\u1ea1n ch\u1ed3ng ch\u00e9o: c\u1ea7m m\u00e1u, vi\u00eam, t\u0103ng sinh v\u00e0 t\u00e1i t\u1ea1o m\u00f4. M\u1eb7c d\u00f9 v\u1ebft th\u01b0\u01a1ng \u0111\u00f3ng m\u1ed9t ph\u1ea7n b\u1eb1ng c\u00e1ch co da, nh\u01b0ng qu\u00e1 tr\u00ecnh t\u00e1i bi\u1ec3u m\u00f4 x\u1ea3y ra trong giai \u0111o\u1ea1n t\u0103ng sinh, l\u00e0 m\u1ed9t b\u01b0\u1edbc quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh ch\u1eefa l\u00e0nh v\u1ebft th\u01b0\u01a1ng.<\/p>\n
Trong qu\u00e1 tr\u00ecnh t\u00e1i bi\u1ec3u m\u00f4, t\u1ebf b\u00e0o s\u1eebng, l\u00e0 nh\u1eefng t\u1ebf b\u00e0o t\u1ea1o n\u00ean l\u1edbp ngo\u00e0i c\u00f9ng c\u1ee7a da, di chuy\u1ec3n l\u00ean tr\u00ean m\u00f4 h\u1ea1t b\u00ean d\u01b0\u1edbi, l\u00e0 m\u00f4 s\u1ea7n, m\u00e0u h\u1ed3ng h\u00ecnh th\u00e0nh xung quanh c\u00e1c c\u1ea1nh c\u1ee7a v\u1ebft th\u01b0\u01a1ng. Cu\u1ed1i c\u00f9ng, c\u00e1c t\u1ebf b\u00e0o s\u1eebng g\u1eb7p c\u00e1c t\u1ebf b\u00e0o s\u1eebng di chuy\u1ec3n t\u1eeb r\u00eca \u0111\u1ed1i di\u1ec7n \u0111\u1ec3 \u0111\u00f3ng v\u1ebft th\u01b0\u01a1ng.<\/p>\n
\u201cM\u1eb7c d\u00f9 c\u00f3 nh\u1eefng ti\u1ebfn b\u1ed9 \u0111\u00e1ng k\u1ec3 trong \u0111i\u1ec1u tr\u1ecb, v\u1eabn c\u00f2n nhi\u1ec1u \u0111i\u1ec1u c\u1ea7n hi\u1ec3u v\u1ec1 c\u00e1c c\u01a1 ch\u1ebf ph\u00e2n t\u1eed li\u00ean quan \u0111\u1ebfn vi\u1ec7c b\u00ecnh th\u01b0\u1eddng T\u00e1c gi\u1ea3 c\u1ea5p cao Bogi Andersen, gi\u00e1o s\u01b0 t\u1ea1i Khoa H\u00f3a sinh v\u00e0 Y h\u1ecdc t\u1ea1i Tr\u01b0\u1eddng Y UCI, cho bi\u1ebft: ch\u1eefa l\u00e0nh v\u1ebft th\u01b0\u01a1ng .<\/p>\n
\u201cNh\u1eefng ph\u00e1t hi\u1ec7n c\u1ee7a ch\u00fang t\u00f4i cho th\u1ea5y nh\u1eefng b\u1ea5t th\u01b0\u1eddng trong con \u0111\u01b0\u1eddng GRHL3 \/ FSCN1 \/ E-cadherin c\u00f3 th\u1ec3 \u0111\u00f3ng vai tr\u00f2 nh\u01b0 th\u1ebf n\u00e0o \u0111\u1ed1i v\u1edbi nh\u1eefng v\u1ebft th\u01b0\u01a1ng kh\u00f4ng l\u00e0nh v\u00e0 c\u1ea7n \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u th\u00eam.\u201d<\/p>\n
Nghi\u00ean c\u1ee9u xu\u1ea5t hi\u1ec7n tr\u00ean JCI Insight.<\/p>\n
H\u1ed7 tr\u1ee3 cho c\u00f4ng vi\u1ec7c n\u00e0y \u0111\u1ebfn t\u1eeb Vi\u1ec7n Y t\u1ebf Qu\u1ed1c gia v\u00e0 Qu\u1ef9 Irving Weinstein.<\/p>\n
Ngu\u1ed3n: Futurity<\/p>\n
S\u00e1ng t\u1ea1o c\u00f3 ph\u01b0\u01a1ng ph\u00e1p s\u1ebd gi\u00fap ch\u00fang ta v\u01b0\u1ee3t qua c\u00e1c l\u1ed1i m\u00f2n t\u01b0 duy. Li\u1ec7u c\u00f3 n\u01a1i n\u00e0o gi\u1ea3ng d\u1ea1y b\u1ea1n c\u00e1ch s\u00e1ng t\u1ea1o? Kho\u00e1 h\u1ecdc ng\u1eafn h\u1ea1n “PH\u01af\u01a0NG PH\u00c1P LU\u1eacN S\u00c1NG T\u1ea0O v\u00e0 \u0110\u1ed4I M\u1edaI<\/a>” \u0111\u01b0\u1ee3c gi\u1ea3ng d\u1ea1y uy t\u00edn, ch\u1ea5t l\u01b0\u1ee3ng t\u1ea1i Trung t\u00e2m S\u00e1ng t\u1ea1o Khoa h\u1ecdc\u2013k\u1ef9 thu\u1eadt (TSK) thu\u1ed9c tr\u01b0\u1eddng Khoa H\u1ecdc T\u1ef1 Nhi\u00ean s\u1ebd l\u1eddi \u0111\u00e1p h\u1eefu \u00edch cho b\u1ea1n. B\u1ea1n c\u00f3 th\u1ec3 \u0111i\u1ec1n th\u00f4ng tin t\u1ea1i \u0111\u00e2y<\/a> ho\u1eb7c li\u00ean h\u1ec7 s\u1ed1 \u0111i\u1ec7n tho\u1ea1i: (028) 38 301 743; 089 668 36 31 \u0111\u1ec3 th\u1ef1c hi\u1ec7n \u0111\u0103ng k\u00fd.<\/p>\n","protected":false},"excerpt":{"rendered":" C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra m\u1ed9t c\u01a1 ch\u1ebf m\u1edbi gi\u00fap th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh ch\u1eefa l\u00e0nh v\u1ebft th\u01b0\u01a1ng tr\u00ean da. Con \u0111\u01b0\u1eddng ph\u00e2n t\u1eed \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1edfi m\u1ed9t … <\/p>\n","protected":false},"author":1,"featured_media":9475,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[82],"tags":[],"yoast_head":"\n