{"id":9455,"date":"2021-08-17T18:23:21","date_gmt":"2021-08-17T11:23:21","guid":{"rendered":"https:\/\/trizgyrus.com\/blogtsk\/?p=9455"},"modified":"2021-08-17T18:23:21","modified_gmt":"2021-08-17T11:23:21","slug":"ban-do-gen-benh-than-co-the-dan-den-cac-phuong-phap-dieu-tri-moi","status":"publish","type":"post","link":"https:\/\/cstc.vn\/blogtsk\/ban-do-gen-benh-than-co-the-dan-den-cac-phuong-phap-dieu-tri-moi\/","title":{"rendered":"B\u1ea3n \u0111\u1ed3 gen b\u1ec7nh th\u1eadn c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi"},"content":{"rendered":"

M\u1ed9t nghi\u00ean c\u1ee9u m\u1edbi cung c\u1ea5p m\u1ed9t trong nh\u1eefng b\u1ee9c tranh r\u00f5 r\u00e0ng nh\u1ea5t cho \u0111\u1ebfn nay v\u1ec1 n\u1ec1n t\u1ea3ng di truy\u1ec1n c\u1ee7a b\u1ec7nh th\u1eadn m\u00e3n t\u00ednh.<\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c 182 gen c\u00f3 kh\u1ea3 n\u0103ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m cho ch\u1ee9c n\u0103ng th\u1eadn – nhi\u1ec1u gen trong s\u1ed1 \u0111\u00f3 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c nh\u1eafm m\u1ee5c ti\u00eau v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c hi\u1ec7n c\u00f3 – v\u00e0 88 gen g\u00e2y t\u0103ng huy\u1ebft \u00e1p.<\/p>\n

Ngo\u00e0i ra, nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 l\u1eadp b\u1ea3n \u0111\u1ed3 c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o v\u00e0 c\u01a1 ch\u1ebf ch\u00ednh c\u00f3 li\u00ean quan \u0111\u1ebfn b\u1ec7nh t\u1eadt.<\/p>\n

M\u1eb7c d\u00f9 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn \u01b0\u1edbc t\u00ednh kho\u1ea3ng 850 tri\u1ec7u ng\u01b0\u1eddi v\u00e0 g\u00e2y ra 1 trong 60 tr\u01b0\u1eddng h\u1ee3p t\u1eed vong tr\u00ean to\u00e0n th\u1ebf gi\u1edbi, nh\u01b0ng r\u1ea5t \u00edt ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn m\u00e3n t\u00ednh c\u00f3 s\u1eb5n. Hi\u1ec3u \u0111\u01b0\u1ee3c c\u00e1c bi\u1ebfn th\u1ec3 di truy\u1ec1n li\u00ean quan \u0111\u1ebfn c\u0103n b\u1ec7nh n\u00e0y l\u00e0 m\u1ed9t b\u01b0\u1edbc quan tr\u1ecdng \u0111\u1ec3 ph\u00e1t tri\u1ec3n thu\u1ed1c.<\/p>\n

Nghi\u00ean c\u1ee9u m\u1edbi m\u1edf \u0111\u01b0\u1eddng cho vi\u1ec7c x\u00e1c \u0111\u1ecbnh c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ti\u1ec1m n\u0103ng, v\u1ed1n r\u1ea5t c\u1ea7n thi\u1ebft, theo \u0111i\u1ec1u tra vi\u00ean ch\u00ednh Katalin Susztak, gi\u00e1o s\u01b0 khoa Th\u1eadn-\u0110i\u1ec7n gi\u1ea3i v\u00e0 T\u0103ng huy\u1ebft \u00e1p t\u1ea1i \u0110\u1ea1i h\u1ecdc Pennsylvania, ng\u01b0\u1eddi \u0111\u1ee9ng \u0111\u1ea7u nghi\u00ean c\u1ee9u c\u00f9ng v\u1edbi t\u00e1c gi\u1ea3 ch\u00ednh Xin Sheng, m\u1ed9t nghi\u00ean c\u1ee9u sinh sau ti\u1ebfn s\u0129.<\/p>\n

Susztak n\u00f3i: \u201c\u0110\u00e2y l\u00e0 m\u1ed9t l\u1ed9 tr\u00ecnh quan tr\u1ecdng \u0111\u1ec3 hi\u1ec3u c\u01a1 ch\u1ebf c\u1ee7a b\u1ec7nh th\u1eadn m\u00e3n t\u00ednh. \u201cMay m\u1eafn thay, m\u1ed9t s\u1ed1 gen m\u00e0 ch\u00fang t\u00f4i \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c \u0111\u1ed1i v\u1edbi b\u1ec7nh th\u1eadn c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c nh\u1eafm m\u1ee5c ti\u00eau b\u1eb1ng c\u00e1c lo\u1ea1i thu\u1ed1c hi\u1ec7n c\u00f3.\u201d<\/p>\n

B\u1ec7nh th\u1eadn m\u00e3n t\u00ednh l\u00e0 m\u1ed9t v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe to\u00e0n c\u1ea7u c\u0169ng nh\u01b0 g\u00e1nh n\u1eb7ng kinh t\u1ebf ng\u00e0y c\u00e0ng t\u0103ng. Theo Trung t\u00e2m Ki\u1ec3m so\u00e1t v\u00e0 Ph\u00f2ng ng\u1eeba D\u1ecbch b\u1ec7nh (CDC), t\u1ed5ng chi ti\u00eau c\u1ee7a Medicare cho b\u1ec7nh nh\u00e2n suy th\u1eadn \u0111\u1ea1t 36,6 t\u1ef7 USD v\u00e0o n\u0103m 2018, chi\u1ebfm kho\u1ea3ng 7% t\u1ed5ng chi ph\u00ed y\u00eau c\u1ea7u b\u1ed3i th\u01b0\u1eddng do Medicare thanh to\u00e1n.<\/p>\n

M\u1eb7c d\u00f9 b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 huy\u1ebft \u00e1p cao \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ec7nh th\u1eadn m\u00e3n t\u00ednh, nh\u01b0ng c\u0103n b\u1ec7nh n\u00e0y c\u00f3 m\u1ed9t y\u1ebfu t\u1ed1 di truy\u1ec1n m\u1ea1nh m\u1ebd v\u00e0 c\u00e1c y\u1ebfu t\u1ed1 di truy\u1ec1n ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn l\u00e0 g\u00f3p ph\u1ea7n v\u00e0o nguy c\u01a1 m\u1eafc b\u1ec7nh.<\/p>\n

\u0110\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 c\u00e1c bi\u1ebfn th\u1ec3 di truy\u1ec1n li\u00ean quan \u0111\u1ebfn b\u1ec7nh th\u1eadn, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 chuy\u1ec3n sang nghi\u00ean c\u1ee9u li\u00ean k\u1ebft to\u00e0n b\u1ed9 b\u1ed9 gen (GWAS), li\u00ean quan \u0111\u1ebfn vi\u1ec7c qu\u00e9t c\u00e1c bi\u1ebfn th\u1ec3 DNA tr\u00ean b\u1ed9 gen ho\u00e0n ch\u1ec9nh c\u1ee7a h\u00e0ng tr\u0103m ngh\u00ecn ng\u01b0\u1eddi. C\u00e1c nghi\u00ean c\u1ee9u di truy\u1ec1n hi\u1ec7n t\u1ea1i \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c kho\u1ea3ng 300 v\u00f9ng trong b\u1ed9 gen ng\u01b0\u1eddi c\u00f3 li\u00ean quan \u0111\u1ebfn b\u1ec7nh th\u1eadn, nh\u01b0ng nh\u1eefng b\u1ea3n \u0111\u1ed3 n\u00e0y kh\u00f4ng th\u1ec3 x\u00e1c \u0111\u1ecbnh c\u00e1c gen, lo\u1ea1i t\u1ebf b\u00e0o v\u00e0 c\u01a1 ch\u1ebf c\u1ee5 th\u1ec3.<\/p>\n

Susztak cho bi\u1ebft: \u201cC\u00e1c b\u1ea3n \u0111\u1ed3 hi\u1ec7n c\u00f3 \u0111\u00e3 ch\u1ec9 ra c\u00e1c khu v\u1ef1c trong b\u1ed9 gen v\u1ec1 kh\u1ea3 n\u0103ng di truy\u1ec1n b\u1ec7nh th\u1eadn, gi\u1ed1ng nh\u01b0 m\u1ed9t b\u1ea3n \u0111\u1ed3 kho b\u00e1u ban \u0111\u1ea7u, nh\u01b0ng cho \u0111\u1ebfn nay, ch\u00fang t\u00f4i v\u1eabn ch\u01b0a bi\u1ebft kho b\u00e1u n\u1eb1m \u1edf \u0111\u00e2u ho\u1eb7c n\u00f3 tr\u00f4ng nh\u01b0 th\u1ebf n\u00e0o. M\u1ee5c ti\u00eau c\u1ee7a ch\u00fang t\u00f4i l\u00e0 t\u00ecm ra v\u1ecb tr\u00ed ch\u00ednh x\u00e1c c\u1ee7a kho b\u00e1u v\u00e0 m\u1edf chi\u1ebfc h\u1ed9p ra \u0111\u1ec3 xem b\u00ean trong c\u00f3 g\u00ec\u201d.<\/p>\n

M\u1ed9t th\u00e1ch th\u1ee9c quan tr\u1ecdng trong vi\u1ec7c d\u1ecbch b\u1ea3n \u0111\u1ed3 gen sang c\u00e1c gen c\u1ee5 th\u1ec3 l\u00e0 h\u1ea7u h\u1ebft c\u00e1c bi\u1ebfn th\u1ec3 di truy\u1ec1n c\u00f3 th\u1ec3 g\u00e2y ra b\u1ec7nh th\u1eadn l\u00e0m thay \u0111\u1ed5i c\u00e1ch th\u1ee9c \u0111i\u1ec1u h\u00f2a c\u00e1c gen. \u0110\u1ec3 v\u01b0\u1ee3t qua th\u00e1ch th\u1ee9c n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 thu th\u1eadp 659 m\u1eabu th\u1eadn c\u1ee7a con ng\u01b0\u1eddi – m\u1ed9t l\u01b0\u1ee3ng l\u1edbn d\u00e2n s\u1ed1. Sau khi m\u1ed5 x\u1ebb th\u1ee7 c\u00f4ng t\u1eebng m\u1eabu m\u00f4, h\u1ecd ph\u00e2n t\u00edch bi\u1ec3u hi\u1ec7n c\u1ee7a t\u1eebng gen v\u00e0 s\u1ef1 bi\u1ebfn \u0111\u1ed5i gen.<\/p>\n

Ti\u1ebfp theo, nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 t\u1ea1o ra d\u1eef li\u1ec7u \u0111i\u1ec1u h\u00f2a v\u00e0 bi\u1ec3u hi\u1ec7n gen cho t\u1eebng lo\u1ea1i t\u1ebf b\u00e0o th\u1eadn c\u1ee7a con ng\u01b0\u1eddi b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p gi\u1ea3i tr\u00ecnh t\u1ef1 t\u1ebf b\u00e0o \u0111\u01a1n m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n. \u0110i\u1ec1u n\u00e0y cho ph\u00e9p c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u x\u00e1c \u0111\u1ecbnh c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o quan tr\u1ecdng m\u00e0 bi\u1ebfn th\u1ec3 di truy\u1ec1n g\u00e2y ra bi\u1ec3u hi\u1ec7n sai c\u1ee7a gen. K\u1ebft qu\u1ea3 c\u1ee7a h\u1ecd \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c g\u1ea7n 200 gen cho ch\u1ee9c n\u0103ng th\u1eadn, c\u0169ng nh\u01b0 g\u1ea7n 100 gen cho b\u1ec7nh t\u0103ng huy\u1ebft \u00e1p. Cu\u1ed1i c\u00f9ng, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 l\u00e0m r\u00f5 c\u01a1 ch\u1ebf \u0111\u1eb1ng sau m\u1ed9t s\u1ed1 hi\u1ec7n c\u00f3 lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn – bao g\u1ed3m thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n v\u00e0 thu\u1ed1c ch\u1eb9n th\u1ee5 th\u1ec3 angiotensin – cho th\u1ea5y r\u1eb1ng ch\u00fang ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c gen li\u00ean quan \u0111\u1ebfn b\u1ec7nh.<\/p>\n

Susztak n\u00f3i: \u201cCh\u00fang t\u00f4i \u0111\u00e3 s\u1eed d\u1ee5ng nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y trong v\u00e0i th\u1eadp k\u1ef7, nh\u01b0ng b\u00e2y gi\u1edd ch\u00fang t\u00f4i bi\u1ebft t\u1ea1i sao ch\u00fang ho\u1ea1t \u0111\u1ed9ng hi\u1ec7u qu\u1ea3 \u0111\u1ebfn v\u1eady. Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e1nh d\u1ea5u m\u1ed9t c\u1ed9t m\u1ed1c quan tr\u1ecdng \u0111\u1ed1i v\u1edbi l\u0129nh v\u1ef1c th\u1eadn h\u1ecdc v\u00e0 h\u00e0ng tri\u1ec7u b\u1ec7nh nh\u00e2n hi\u1ec7n \u0111ang b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi b\u1ec7nh th\u1eadn m\u00e3n t\u00ednh\u201d.<\/p>\n

C\u00e1c ph\u00e1t hi\u1ec7n xu\u1ea5t hi\u1ec7n tr\u00ean Nature Genetics.<\/p>\n

H\u1ed7 tr\u1ee3 cho nghi\u00ean c\u1ee9u n\u00e0y \u0111\u1ebfn t\u1eeb Vi\u1ec7n Y t\u1ebf Qu\u1ed1c gia v\u00e0 b\u1edfi Qu\u1ef9 c\u1ee7a D\u1ef1 \u00e1n \u0110\u1ed1i t\u00e1c Y h\u1ecdc T\u0103ng t\u1ed1c B\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2 NIH.<\/p>\n

Ngu\u1ed3n: Futurity<\/p>\n

S\u00e1ng t\u1ea1o l\u00e0 s\u1ee9c h\u00fat di\u1ec7u k\u1ef3 \u0111\u1ec3 b\u1ea1n tr\u1edf n\u00ean kh\u00e1c bi\u1ec7t v\u00e0 \u0111a n\u0103ng trong c\u00f4ng vi\u1ec7c, cu\u1ed9c s\u1ed1ng. C\u00f4ng c\u1ee5 m\u1ea1nh trong t\u01b0 duy s\u00e1ng t\u1ea1o s\u1ebd gi\u00fap b\u1ea1n tr\u1edf th\u00e0nh m\u1ed9t ng\u01b0\u1eddi \u0111\u1ea7y t\u1ef1 tin nh\u01b0 th\u1ebf. N\u1ebfu \u0111\u00e3 t\u1eebng bi\u1ebft \u0111\u1ebfn Kho\u00e1 h\u1ecdc “PH\u01af\u01a0NG PH\u00c1P LU\u1eacN S\u00c1NG T\u1ea0O v\u00e0 \u0110\u1ed4I M\u1edaI<\/a>” \u0111\u01b0\u1ee3c gi\u1ea3ng d\u1ea1y uy t\u00edn, ch\u1ea5t l\u01b0\u1ee3ng t\u1ea1i Trung t\u00e2m S\u00e1ng t\u1ea1o Khoa h\u1ecdc\u2013k\u1ef9 thu\u1eadt (TSK) thu\u1ed9c tr\u01b0\u1eddng Khoa H\u1ecdc T\u1ef1 Nhi\u00ean th\u00ec b\u1ea1n h\u00e3y nhanh ch\u00f3ng \u0111\u0103ng k\u00fd nh\u00e9. B\u1ea1n c\u00f3 th\u1ec3 \u0111i\u1ec1n th\u00f4ng tin t\u1ea1i \u0111\u00e2y<\/a> ho\u1eb7c li\u00ean h\u1ec7 s\u1ed1 \u0111i\u1ec7n tho\u1ea1i: (028) 38 301 743; 089 668 36 31 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n c\u1ee5 th\u1ec3.<\/p>\n","protected":false},"excerpt":{"rendered":"

M\u1ed9t nghi\u00ean c\u1ee9u m\u1edbi cung c\u1ea5p m\u1ed9t trong nh\u1eefng b\u1ee9c tranh r\u00f5 r\u00e0ng nh\u1ea5t cho \u0111\u1ebfn nay v\u1ec1 n\u1ec1n t\u1ea3ng di truy\u1ec1n c\u1ee7a b\u1ec7nh th\u1eadn m\u00e3n t\u00ednh. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c … <\/p>\n","protected":false},"author":1,"featured_media":9456,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[82],"tags":[],"yoast_head":"\nB\u1ea3n \u0111\u1ed3 gen b\u1ec7nh th\u1eadn c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi - Blog TSK<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cstc.vn\/blogtsk\/ban-do-gen-benh-than-co-the-dan-den-cac-phuong-phap-dieu-tri-moi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"B\u1ea3n \u0111\u1ed3 gen b\u1ec7nh th\u1eadn c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi - Blog TSK\" \/>\n<meta property=\"og:description\" content=\"M\u1ed9t nghi\u00ean c\u1ee9u m\u1edbi cung c\u1ea5p m\u1ed9t trong nh\u1eefng b\u1ee9c tranh r\u00f5 r\u00e0ng nh\u1ea5t cho \u0111\u1ebfn nay v\u1ec1 n\u1ec1n t\u1ea3ng di truy\u1ec1n c\u1ee7a b\u1ec7nh th\u1eadn m\u00e3n t\u00ednh. 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